Interferon alfa-2a
Roferon-A (interferon alfa-2a) is a protein pharmaceutical. Interferon alfa-2a was first approved as Roferon-a on 1986-06-04. It is used to treat brain neoplasms, chronic hepatitis c, colorectal neoplasms, cryoglobulinemia, and essential thrombocythemia amongst others in the USA.
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Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
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Biosimilar product - 351(k)
Biosimilar product - 351(k)
Interferon alfa-2a
Tradename | Proper name | Company | Number | Date | Products |
|---|---|---|---|---|---|
| Roferon-A | interferon alfa-2a | Hoffmann-La Roche Inc. | N-103145 DISCN | 1986-06-04 | 1 products |
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HCPCS
Code | Description |
|---|---|
| S0145 | Injection, pegylated interferon alfa-2a, 180 mcg per ml |
Clinical
Clinical Trials
668 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | 6 | 63 | 62 | 61 | 32 | 216 |
| Hepatitis c | D006526 | — | B19.2 | 6 | 33 | 40 | 23 | 11 | 105 |
| Chronic hepatitis b | D019694 | EFO_0004239 | B18.1 | 12 | 27 | 18 | 40 | 13 | 102 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 11 | 22 | 10 | 6 | 3 | 47 |
| Hepatitis b | D006509 | — | — | — | 5 | 6 | 3 | 8 | 21 |
| Neoplasms | D009369 | — | C80 | 8 | 4 | — | 1 | — | 12 |
| Hepacivirus | D016174 | — | — | — | 7 | 4 | 1 | 1 | 12 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | 3 | 2 | 2 | 1 | 8 |
| Chronic hepatitis | D006521 | — | K73.9 | 1 | 3 | 3 | 1 | — | 7 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 2 | 2 | 2 | 1 | 1 | 6 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanoma | D008545 | — | — | 12 | 11 | 8 | — | 1 | 31 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 3 | 13 | 3 | — | 1 | 17 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 1 | 6 | — | 6 | 12 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 1 | 4 | 5 | — | — | 8 |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 1 | 5 | 1 | — | — | 7 |
| Polycythemia vera | D011087 | — | D45 | 1 | 1 | 4 | — | — | 6 |
| Essential thrombocythemia | D013920 | — | D47.3 | 1 | 2 | 1 | — | — | 4 |
| Recurrence | D012008 | — | — | 1 | 2 | 3 | — | — | 4 |
| Covid-19 | D000086382 | — | U07.1 | 2 | 3 | 1 | — | — | 3 |
| Multiple myeloma | D009101 | — | C90.0 | — | 1 | 2 | — | — | 3 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 5 | 3 | — | — | — | 6 |
| Kaposi sarcoma | D012514 | — | C46 | 3 | 2 | — | — | — | 5 |
| Leukemia | D007938 | — | C95 | 2 | 2 | — | — | 1 | 4 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 4 | 4 | — | — | — | 4 |
| Hepatitis d | D003699 | EFO_0007304 | — | — | 3 | — | — | — | 3 |
| Fibrosis | D005355 | — | — | — | 1 | — | — | 2 | 3 |
| Prostatic neoplasms | D011471 | — | C61 | — | 2 | — | — | — | 2 |
| Adenocarcinoma | D000230 | — | — | — | 2 | — | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | — | 2 | — | — | — | 2 |
| Squamous cell carcinoma | D002294 | — | — | 1 | 1 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 7 | — | — | — | 1 | 8 |
| Triple negative breast neoplasms | D064726 | — | — | 2 | — | — | — | — | 2 |
| Psoriasis | D011565 | EFO_0000676 | L40 | 1 | — | — | — | — | 1 |
| Anus neoplasms | D001005 | EFO_0003835 | C21 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Intravenous substance abuse | D015819 | — | — | — | — | — | — | 1 | 1 |
| Medication adherence | D055118 | EFO_0006344 | — | — | — | — | — | 1 | 1 |
| Progressive multifocal leukoencephalopathy | D007968 | EFO_0007455 | A81.2 | — | — | — | — | 1 | 1 |
| Ascites | D001201 | HP_0001541 | R18 | — | — | — | — | 1 | 1 |
| Esophageal and gastric varices | D004932 | EFO_0009545 | I85 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Interferon alfa-2a |
| INN | — |
| Description | Pegylated interferon alfa-2a, sold under the brand name Pegasys among others, is medication used to treat hepatitis C and hepatitis B. For hepatitis C it is typically used together with ribavirin and cure rates are between 24 and 92%. For hepatitis B it may be used alone. It is given by injection under the skin.
|
| Classification | Protein |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | 120608 |
| ChEMBL ID | CHEMBL2108508 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00008 |
| UNII ID | — |
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Additional graphs summarizing 41 documents
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29,773 adverse events reported
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